Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network

Hypothalamic POMC deficiency leads to obesity and metabolic deficiencies, largely due to the loss of melanocortin peptides. However, POMC neurons in the arcuate nucleus (ARC) are comprised of glutamatergic and GABAergic subpopulations. The developmental program, relative proportion and function of t...

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Udgivet i:eNeuro
Main Authors: Jones, Graham L., Wittmann, Gábor, Yokosawa, Eva B., Yu, Hui, Mercer, Aaron J., Lechan, Ronald M., Low, Malcolm J.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2019
Fag:
New Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449166/
https://ncbi.nlm.nih.gov/pubmed/30957016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0400-18.2019
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