Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice

The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as...

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Detaylı Bibliyografya
Yayımlandı:Iran J Pharm Res
Asıl Yazarlar: Yousefi, Gholamhossein, Shafaati, Alireza, Zarghi, Afshin, Foroutan, Seyed Mohsen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Shaheed Beheshti University of Medical Sciences 2018
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447882/
https://ncbi.nlm.nih.gov/pubmed/31011346
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