Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression

Programmed cell death ligand 1 (PD‐L1) on tumor cells suppresses anti‐tumor immunity and has an unfavorable prognostic impact in ovarian cancer patients. We herein report the pathophysiological and therapeutic impacts of PD‐L1 disruption in ovarian cancer. PD‐L1 was genetically disrupted in the muri...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Yahata, Tamaki, Mizoguchi, Mika, Kimura, Akihiko, Orimo, Takashi, Toujima, Saori, Kuninaka, Yumi, Nosaka, Mizuho, Ishida, Yuko, Sasaki, Izumi, Fukuda‐Ohta, Yuri, Hemmi, Hiroaki, Iwahashi, Naoyuki, Noguchi, Tomoko, Kaisho, Tsuneyasu, Kondo, Toshikazu, Ino, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447841/
https://ncbi.nlm.nih.gov/pubmed/30702189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13958
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