Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression

Programmed cell death ligand 1 (PD‐L1) on tumor cells suppresses anti‐tumor immunity and has an unfavorable prognostic impact in ovarian cancer patients. We herein report the pathophysiological and therapeutic impacts of PD‐L1 disruption in ovarian cancer. PD‐L1 was genetically disrupted in the muri...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Yahata, Tamaki, Mizoguchi, Mika, Kimura, Akihiko, Orimo, Takashi, Toujima, Saori, Kuninaka, Yumi, Nosaka, Mizuho, Ishida, Yuko, Sasaki, Izumi, Fukuda‐Ohta, Yuri, Hemmi, Hiroaki, Iwahashi, Naoyuki, Noguchi, Tomoko, Kaisho, Tsuneyasu, Kondo, Toshikazu, Ino, Kazuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447841/
https://ncbi.nlm.nih.gov/pubmed/30702189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13958
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