Local Administration of GITR Agonistic Antibody Induces a Stronger Antitumor Immunity than Systemic Delivery

An anti-glucocorticoid induced TNF receptor (GITR) agonistic antibody (Ab) induces an antitumor immunity with both stimulation of effector T cells and inhibition of regulatory T cell activity. To enhance GITR Ab-mediated tumor immunity, we focused on the intratumoral route, since a tumor-localized h...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Narumi, Kenta, Miyakawa, Reina, Shibasaki, Chihiro, Henmi, Marina, Mizoguchi, Yukihiro, Ueda, Ryosuke, Hashimoto, Hisayoshi, Hiraoka, Nobuyoshi, Yoshida, Teruhiko, Aoki, Kazunori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447616/
https://ncbi.nlm.nih.gov/pubmed/30944344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41724-x
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