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GITR drives T(H)9-mediated antitumor immunity
T(H)9 cells have been implicated in triggering antitumor immunity. We have identified that GITR co-stimulation inhibits iT(reg) cell generation but drives T(H)9 cell differentiation, thereby suppressing tumor growth via enhancing the function of DCs and CTLs in vivo. Our findings provide novel mecha...
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| Publicado no: | Oncoimmunology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4910720/ https://ncbi.nlm.nih.gov/pubmed/27467921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1122862 |
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