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Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity
Tumor progression is facilitated immunologically by mechanisms that include low antigen expression, an absence of coimmunostimulatory signals, and the presence of regulatory T cells (Tregs), all of which act to suppress and restrict effector T cells in the tumor. It may be possible to overcome these...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5503599/ https://ncbi.nlm.nih.gov/pubmed/28388572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16605 |
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