Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity

Tumor progression is facilitated immunologically by mechanisms that include low antigen expression, an absence of coimmunostimulatory signals, and the presence of regulatory T cells (Tregs), all of which act to suppress and restrict effector T cells in the tumor. It may be possible to overcome these...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Villarreal, Daniel O., Chin, Diana, Smith, Melissa A., Luistro, Leopoldo L., Snyder, Linda A.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2017
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503599/
https://ncbi.nlm.nih.gov/pubmed/28388572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16605
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