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PD-1 or PD-L1 Blockade Restores Antitumor Efficacy Following SSX2 Epitope-Modified DNA Vaccine Immunization

DNA vaccines have demonstrated antitumor efficacy in multiple preclinical models, but low immunogenicity has been observed in several human clinical trials. This has led to many approaches seeking to improve the immunogenicity of DNA vaccines. We previously reported that a DNA vaccine encoding the c...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Rekoske, Brian T., Smith, Heath A., Olson, Brian M., Maricque, Brett B., McNeel, Douglas G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527948/
https://ncbi.nlm.nih.gov/pubmed/26041735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0206
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