Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass s...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Yang, Minjun, Vesterlund, Mattias, Siavelis, Ioannis, Moura-Castro, Larissa H., Castor, Anders, Fioretos, Thoas, Jafari, Rozbeh, Lilljebjörn, Henrik, Odom, Duncan T., Olsson, Linda, Ravi, Naveen, Woodward, Eleanor L., Harewood, Louise, Lehtiö, Janne, Paulsson, Kajsa
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447538/
https://ncbi.nlm.nih.gov/pubmed/30944321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09469-3
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