Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass s...

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Publicado en:Nat Commun
Autores principales: Yang, Minjun, Vesterlund, Mattias, Siavelis, Ioannis, Moura-Castro, Larissa H., Castor, Anders, Fioretos, Thoas, Jafari, Rozbeh, Lilljebjörn, Henrik, Odom, Duncan T., Olsson, Linda, Ravi, Naveen, Woodward, Eleanor L., Harewood, Louise, Lehtiö, Janne, Paulsson, Kajsa
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447538/
https://ncbi.nlm.nih.gov/pubmed/30944321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09469-3
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