Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass s...

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Publicado no:Nat Commun
Main Authors: Yang, Minjun, Vesterlund, Mattias, Siavelis, Ioannis, Moura-Castro, Larissa H., Castor, Anders, Fioretos, Thoas, Jafari, Rozbeh, Lilljebjörn, Henrik, Odom, Duncan T., Olsson, Linda, Ravi, Naveen, Woodward, Eleanor L., Harewood, Louise, Lehtiö, Janne, Paulsson, Kajsa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447538/
https://ncbi.nlm.nih.gov/pubmed/30944321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09469-3
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