Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy

Severe side effects often restrict clinical application of the widely used chemotherapeutic drug doxorubicin. In order to decrease required substance concentrations, new concepts for successful combination therapy are needed. Since doxorubicin causes DNA damage, combination with compounds that modul...

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Publicado en:Cell Death Dis
Autores principales: Pfitzer, Lisa, Moser, Christina, Gegenfurtner, Florian, Arner, Anja, Foerster, Florian, Atzberger, Carina, Zisis, Themistoklis, Kubisch-Dohmen, Rebekka, Busse, Johanna, Smith, Rebecca, Timinszky, Gyula, Kalinina, Olga V., Müller, Rolf, Wagner, Ernst, Vollmar, Angelika M., Zahler, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447524/
https://ncbi.nlm.nih.gov/pubmed/30944311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1546-9
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