Structure of human TFIID and mechanism of TBP loading onto promoter DNA

The general transcription factor IID (TFIID) is a critical component of the eukaryotic transcription preinitiation complex (PIC) and is responsible for recognizing the core promoter DNA and initiating PIC assembly. We used cryo-electron microscopy (cryo-EM), chemical crosslinking-mass spectrometry (...

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Udgivet i:Science
Main Authors: Patel, Avinash B., Louder, Robert K., Greber, Basil J., Grünberg, Sebastian, Luo, Jie, Fang, Jie, Liu, Yutong, Ranish, Jeff, Hahn, Steve, Nogales, Eva
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446905/
https://ncbi.nlm.nih.gov/pubmed/30442764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau8872
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