Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Hepatic iron overload is a risk factor for progression of hepatocellular carcinoma (HCC), although the molecular mechanisms underlying this association have remained unclear. We now show that the iron-sensing ubiquitin ligase FBXL5 is a previously unrecognized oncosuppressor in liver carcinogenesis...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Muto, Yoshiharu, Moroishi, Toshiro, Ichihara, Kazuya, Nishiyama, Masaaki, Shimizu, Hideyuki, Eguchi, Hidetoshi, Moriya, Kyoji, Koike, Kazuhiko, Mimori, Koshi, Mori, Masaki, Katayama, Yuta, Nakayama, Keiichi I.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446870/
https://ncbi.nlm.nih.gov/pubmed/30877170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180900
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