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Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
Hematopoietic stem cells (HSCs) are maintained in a hypoxic niche to limit oxidative stress. Although iron elicits oxidative stress, the importance of iron homeostasis in HSCs has been unknown. Here we show that iron regulation by the F-box protein FBXL5 is required for HSC self-renewal. Conditional...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5520054/ https://ncbi.nlm.nih.gov/pubmed/28714470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16114 |
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