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HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism
FBXL5 (F-box and leucine-rich repeat protein 5) is the F-box protein subunit of, and therefore responsible for substrate recognition by, the SCF(FBXL5) ubiquitin-ligase complex, which targets iron regulatory protein 2 (IRP2) for proteasomal degradation. IRP2 plays a central role in the maintenance o...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047410/ https://ncbi.nlm.nih.gov/pubmed/24778179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541490 |
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