F-box and Leucine-rich Repeat Protein 5 (FBXL5) Is Required for Maintenance of Cellular and Systemic Iron Homeostasis

Maintenance of cellular iron homeostasis requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2). The hemerythrin-like domain of F-box and leucine-rich repeat protein 5 (FBXL5), an E3 ubiquitin ligase subunit, senses iron and oxygen availability and faci...

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Bibliografiske detaljer
Main Authors: Ruiz, Julio C., Walker, Scott D., Anderson, Sheila A., Eisenstein, Richard S., Bruick, Richard K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537052/
https://ncbi.nlm.nih.gov/pubmed/23135277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426171
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