Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5) Communicates Cellular Iron and Oxygen Availability by Distinct Mechanisms

Iron regulatory proteins play a principal role in maintaining cellular iron homeostasis by post-transcriptionally regulating factors responsible for iron uptake, utilization, and storage. An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 for proteasomal degradation under iron- and oxygen-...

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Main Authors: Chollangi, Srinivas, Thompson, Joel W., Ruiz, Julio C., Gardner, Kevin H., Bruick, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390645/
https://ncbi.nlm.nih.gov/pubmed/22648410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360404
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