Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis

The lectin-like oxidized LDL receptor 1 (LOX-1) is a key player in the development of atherosclerosis. LOX-1 promotes endothelial activation and dysfunction by mediating uptake of oxidized LDL and inducing pro-atherogenic signaling. However, little is known about modulators of LOX-1–mediated respons...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Mentrup, Torben, Theodorou, Kosta, Cabrera-Cabrera, Florencia, Helbig, Andreas O., Happ, Kathrin, Gijbels, Marion, Gradtke, Ann-Christine, Rabe, Björn, Fukumori, Akio, Steiner, Harald, Tholey, Andreas, Fluhrer, Regina, Donners, Marjo, Schröder, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446863/
https://ncbi.nlm.nih.gov/pubmed/30819724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171438
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