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MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

Cyclin B–dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter role is mediated through phosphorylation of the checkpoint kinase MPS1 and other spindle checkpoint proteins. We find that CDK1-CCNB1 localizes...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Alfonso-Pérez, Tatiana, Hayward, Daniel, Holder, James, Gruneberg, Ulrike, Barr, Francis A.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446853/
https://ncbi.nlm.nih.gov/pubmed/30674583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201808015
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