CD96 is an immune checkpoint that regulates CD8(+) T-cell antitumor function

CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor models in a CD8(+) T cell–dependent manner. DNAM-1/CD226, Batf3, IL12p35, and I...

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Vydáno v:Cancer Immunol Res
Hlavní autoři: Mittal, Deepak, Lepletier, Ailin, Madore, Jason, Aguilera, Amelia Roman, Stannard, Kimberley, Blake, Stephen J., Whitehall, Vicki L. J., Liu, Cheng, Bettington, Mark L., Takeda, Kazuyoshi, Long, Georgina V., Scolyer, Richard A., Lan, Ruth, Siemers, Nathan, Korman, Alan, Teng, Michele W. L., Johnston, Robert, Dougall, William C, Smyth, Mark J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445751/
https://ncbi.nlm.nih.gov/pubmed/30894377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0637
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