Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

Multiple non-redundant immunosuppressive pathways co-exist in the tumor microenvironment and their co-targeting can increase clinical responses. Indeed, concurrent blockade of CTLA-4 and PD-1 in patients with advanced melanoma increased clinical responses over monotherapy alone although the frequenc...

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Foilsithe in:Oncoimmunology
Main Authors: Harjunpää, Heidi, Blake, Stephen J., Ahern, Elizabeth, Allen, Stacey, Liu, Jing, Yan, Juming, Lutzky, Viviana, Takeda, Kazuyoshi, Aguilera, Amy Roman, Guillerey, Camille, Mittal, Deepak, Li, Xian Yang, Dougall, William C., Smyth, Mark J., Teng, Michele W. L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2018
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993492/
https://ncbi.nlm.nih.gov/pubmed/29900061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1445949
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