CD96 is an immune checkpoint that regulates CD8(+) T-cell antitumor function

CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor models in a CD8(+) T cell–dependent manner. DNAM-1/CD226, Batf3, IL12p35, and I...

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Publicado no:Cancer Immunol Res
Main Authors: Mittal, Deepak, Lepletier, Ailin, Madore, Jason, Aguilera, Amelia Roman, Stannard, Kimberley, Blake, Stephen J., Whitehall, Vicki L. J., Liu, Cheng, Bettington, Mark L., Takeda, Kazuyoshi, Long, Georgina V., Scolyer, Richard A., Lan, Ruth, Siemers, Nathan, Korman, Alan, Teng, Michele W. L., Johnston, Robert, Dougall, William C, Smyth, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445751/
https://ncbi.nlm.nih.gov/pubmed/30894377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0637
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