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Challenges for the clinical development of PI3K inhibitors: Strategies to improve their impact in solid tumors
The PI3K pathway is mutated and aberrantly activated in many cancers and plays a central role in tumor cell proliferation and survival, making it a rational therapeutic target. To date, however, results from clinical trials with PI3K inhibitors in solid tumors have been largely disappointing. Here,...
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| Publicado no: | Cancer Discov |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6445714/ https://ncbi.nlm.nih.gov/pubmed/30867161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1175 |
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