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Challenges in the clinical development of PI3K inhibitors
The PI3K/Akt/mTOR pathway is one of the most frequently dysregulated signaling pathways in cancer and an important target for drug development. PI3K signaling plays a fundamental role in tumorigenesis, governing cell proliferation, survival, motility, and angiogenesis. Activation of the pathway is f...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Publishing Ltd
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3666091/ https://ncbi.nlm.nih.gov/pubmed/23551097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12060 |
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