SPHK1 is a novel target of metformin in ovarian cancer

The role of phospholipid signaling in ovarian cancer (OvCa) is poorly understood. Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingosine that has been associated with tumor progression through enhanced cell proliferation and motility. Similarly, sphingosine kinases (SPHK), which cata...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cancer Res
Prif Awduron: Hart, Peter C., Chiyoda, Tatsuyuki, Liu, Xiaojing, Weigert, Melanie, Curtis, Marion, Chiang, Chun-Yi, Loth, Rachel, Lastra, Ricardo, McGregor, Stephanie M., Locasale, Jason W., Lengyel, Ernst, Romero, Iris L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445689/
https://ncbi.nlm.nih.gov/pubmed/30655321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0409
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