NUCLEAR-CYTOPLASMIC TRANSPORT IS A THERAPEUTIC TARGET IN MYELOFIBROSIS

PURPOSE: Myelofibrosis (MF) is a hematopoietic stem cell neoplasm characterized by bone marrow reticulin fibrosis, extramedullary hematopoiesis, and frequent transformation to acute myeloid leukemia. Constitutive activation of JAK/STAT signaling through mutations in JAK2, CALR, or MPL is central to...

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Published in:Clin Cancer Res
Main Authors: Yan, Dongqing, Pomicter, Anthony D., Tantravahi, Srinivas K., Mason, Clinton C., Senina, Anna V., Ahmann, Jonathan M., Wang, Qiang, Than, Hein, Patel, Ami B., Heaton, William L., Eiring, Anna M., Clair, Phillip M., Gantz, Kevin C., Redwine, Hannah M., Swierczek, Sabina I., Halverson, Brayden J., Baloglu, Erkan, Shacham, Sharon, Khorashad, Jamshid S., Kelley, Todd W., Salama, Mohamed E., Miles, Rodney R., Boucher, Kenneth M., Prchal, Josef T., O'Hare, Thomas, Deininger, Michael W.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445677/
https://ncbi.nlm.nih.gov/pubmed/30563936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0959
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