NUCLEAR-CYTOPLASMIC TRANSPORT IS A THERAPEUTIC TARGET IN MYELOFIBROSIS

PURPOSE: Myelofibrosis (MF) is a hematopoietic stem cell neoplasm characterized by bone marrow reticulin fibrosis, extramedullary hematopoiesis, and frequent transformation to acute myeloid leukemia. Constitutive activation of JAK/STAT signaling through mutations in JAK2, CALR, or MPL is central to...

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Publicado en:Clin Cancer Res
Autores principales: Yan, Dongqing, Pomicter, Anthony D., Tantravahi, Srinivas K., Mason, Clinton C., Senina, Anna V., Ahmann, Jonathan M., Wang, Qiang, Than, Hein, Patel, Ami B., Heaton, William L., Eiring, Anna M., Clair, Phillip M., Gantz, Kevin C., Redwine, Hannah M., Swierczek, Sabina I., Halverson, Brayden J., Baloglu, Erkan, Shacham, Sharon, Khorashad, Jamshid S., Kelley, Todd W., Salama, Mohamed E., Miles, Rodney R., Boucher, Kenneth M., Prchal, Josef T., O'Hare, Thomas, Deininger, Michael W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445677/
https://ncbi.nlm.nih.gov/pubmed/30563936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0959
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