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Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

BACKGROUND: Sialic acid–binding immunoglobulin-like lectin (Siglec)-8 is a cell-surface protein expressed selectively on human eosinophils, mast cells, and basophils, making it an ideal target for the treatment of diseases involving these cell types. However, the effective delivery of therapeutic ag...

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Detalles Bibliográficos
Publicado en:J Allergy Clin Immunol
Autores principales: O’Sullivan, Jeremy A., Carroll, Daniela J., Cao, Yun, Salicru, Adriano N., Bochner, Bruce S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445644/
https://ncbi.nlm.nih.gov/pubmed/28734845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.06.028
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