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Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: mechanisms and pitfalls

Eosinophils are important multifunctional granulocytes. When studying eosinophil function and its contribution to diseases, mouse models are often used. Mouse eosinophils selectively express sialic acid-binding immunoglobulin-like lectin (Siglec)-F. Its closest functional paralog on human eosinophil...

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Podrobná bibliografie
Vydáno v:J Leukoc Biol
Hlavní autoři: Knuplez, Eva, Krier-Burris, Rebecca, Cao, Yun, Marsche, Gunther, O’Sullivan, Jeremy, Bochner, Bruce S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585130/
https://ncbi.nlm.nih.gov/pubmed/32134149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.3HI0120-381R
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