Siglec-8 is an activating receptor mediating β2 integrin-dependent function in human eosinophils

BACKGROUND: Siglec-8 is a CD33 subfamily cell surface receptor that is selectively expressed on human eosinophils. Following cytokine-priming, Siglec-8 mAb or glycan ligand binding causes eosinophil apoptosis associated with reactive oxygen species (ROS) production. Most CD33-related Siglecs functio...

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Bibliografiset tiedot
Julkaisussa:J Allergy Clin Immunol
Päätekijät: Carroll, Daniela J., O’Sullivan, Jeremy A., Nix, David B., Cao, Yun, Tiemeyer, Michael, Bochner, Bruce S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839929/
https://ncbi.nlm.nih.gov/pubmed/28888781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.08.013
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