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Siglec-8 is an activating receptor mediating β2 integrin-dependent function in human eosinophils
BACKGROUND: Siglec-8 is a CD33 subfamily cell surface receptor that is selectively expressed on human eosinophils. Following cytokine-priming, Siglec-8 mAb or glycan ligand binding causes eosinophil apoptosis associated with reactive oxygen species (ROS) production. Most CD33-related Siglecs functio...
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| Опубликовано в: : | J Allergy Clin Immunol |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839929/ https://ncbi.nlm.nih.gov/pubmed/28888781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.08.013 |
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