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Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

BACKGROUND: Sialic acid–binding immunoglobulin-like lectin (Siglec)-8 is a cell-surface protein expressed selectively on human eosinophils, mast cells, and basophils, making it an ideal target for the treatment of diseases involving these cell types. However, the effective delivery of therapeutic ag...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Allergy Clin Immunol
Prif Awduron: O’Sullivan, Jeremy A., Carroll, Daniela J., Cao, Yun, Salicru, Adriano N., Bochner, Bruce S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445644/
https://ncbi.nlm.nih.gov/pubmed/28734845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.06.028
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