R‐ and S‐citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation

AIMS: The aim was to determine the relationship between (R) and (S)‐citalopram enantiomer exposure (AUC(0,24 h)) and therapeutic response in agitated individuals greater than 60 years old with Alzheimer's dementia (AD). METHODS: Citalopram enantiomer exposures (AUC(0,24 h)) derived from an esta...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Ho, Thang, Pollock, Bruce G., Mulsant, Benoit H., Schantz, Oliver, Devanand, Devangere P., Mintzer, Jacobo E., Porsteinsson, Anton P., Schneider, Lon S., Weintraub, Daniel, Yesavage, Jerome, Drye, Lea T., Munro, Cynthia A., Shade, David M., Lyketsos, Constantine, Bies, Robert
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Pharmacokinetic Dynamic Relationships
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445501/
https://ncbi.nlm.nih.gov/pubmed/27145364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12997
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