A population pharmacokinetic model for R- and S-citalopram and desmethylcitalopram in Alzheimer’s disease patients with agitation

The citalopram for Alzheimer’s disease trial evaluated citalopram for the management for agitation in Alzheimer’s disease patients. Sparse data was available from this elderly patient population. A nonlinear mixed effects population pharmacokinetic modeling approach was used to describe the pharmaco...

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Veröffentlicht in:J Pharmacokinet Pharmacodyn
Hauptverfasser: Akil, Ayman, Bies, Robert R., Pollock, Bruce G., Avramopoulos, Dimitrios, Devanand, D. P., Mintzer, Jacobo E., Porsteinsson, Anton P., Schneider, Lon S., Weintraub, Daniel, Yesavage, Jerome, Shade, David M., Lyketsos, Constantine G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2015
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720707/
https://ncbi.nlm.nih.gov/pubmed/26611790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-015-9457-6
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