A population pharmacokinetic model for R- and S-citalopram and desmethylcitalopram in Alzheimer’s disease patients with agitation

The citalopram for Alzheimer’s disease trial evaluated citalopram for the management for agitation in Alzheimer’s disease patients. Sparse data was available from this elderly patient population. A nonlinear mixed effects population pharmacokinetic modeling approach was used to describe the pharmaco...

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Detalhes bibliográficos
Publicado no:J Pharmacokinet Pharmacodyn
Main Authors: Akil, Ayman, Bies, Robert R., Pollock, Bruce G., Avramopoulos, Dimitrios, Devanand, D. P., Mintzer, Jacobo E., Porsteinsson, Anton P., Schneider, Lon S., Weintraub, Daniel, Yesavage, Jerome, Shade, David M., Lyketsos, Constantine G.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720707/
https://ncbi.nlm.nih.gov/pubmed/26611790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-015-9457-6
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