R‐ and S‐citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation

AIMS: The aim was to determine the relationship between (R) and (S)‐citalopram enantiomer exposure (AUC(0,24 h)) and therapeutic response in agitated individuals greater than 60 years old with Alzheimer's dementia (AD). METHODS: Citalopram enantiomer exposures (AUC(0,24 h)) derived from an esta...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Ho, Thang, Pollock, Bruce G., Mulsant, Benoit H., Schantz, Oliver, Devanand, Devangere P., Mintzer, Jacobo E., Porsteinsson, Anton P., Schneider, Lon S., Weintraub, Daniel, Yesavage, Jerome, Drye, Lea T., Munro, Cynthia A., Shade, David M., Lyketsos, Constantine, Bies, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Pharmacokinetic Dynamic Relationships
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445501/
https://ncbi.nlm.nih.gov/pubmed/27145364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12997
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