R‐ and S‐citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation

AIMS: The aim was to determine the relationship between (R) and (S)‐citalopram enantiomer exposure (AUC(0,24 h)) and therapeutic response in agitated individuals greater than 60 years old with Alzheimer's dementia (AD). METHODS: Citalopram enantiomer exposures (AUC(0,24 h)) derived from an esta...

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Detalles Bibliográficos
Publicado en:Br J Clin Pharmacol
Main Authors: Ho, Thang, Pollock, Bruce G., Mulsant, Benoit H., Schantz, Oliver, Devanand, Devangere P., Mintzer, Jacobo E., Porsteinsson, Anton P., Schneider, Lon S., Weintraub, Daniel, Yesavage, Jerome, Drye, Lea T., Munro, Cynthia A., Shade, David M., Lyketsos, Constantine, Bies, Robert
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Pharmacokinetic Dynamic Relationships
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445501/
https://ncbi.nlm.nih.gov/pubmed/27145364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12997
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