Homolog-selective degradation as a strategy to probe the function of CDK6 in AML

The design of selective small-molecules is often stymied by similar ligand binding pockets. Here, we report BSJ-03–123, a phthalimide-based degrader that exploits protein-interface determinants to achieve proteome-wide selectivity for the degradation of cyclin-dependent kinase 6 (CDK6). Pharmacologi...

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I publikationen:Cell Chem Biol
Huvudupphovsmän: Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A., Wang, Eric S., Nowak, Radosław P., Yuan, Jingting C., Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C., Fischer, Eric S., Gray, Nathanael S., Winter, Georg E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444916/
https://ncbi.nlm.nih.gov/pubmed/30595531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.11.006
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