Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis

Rationale: Neutrophils are recruited to the airways of individuals with cystic fibrosis (CF). In adolescents and adults with CF, airway neutrophils actively exocytose the primary granule protease elastase (NE), whose extracellular activity correlates with lung damage. During childhood, free extracel...

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Detaylı Bibliyografya
Yayımlandı:Am J Respir Crit Care Med
Asıl Yazarlar: Margaroli, Camilla, Garratt, Luke W., Horati, Hamed, Dittrich, A. Susanne, Rosenow, Timothy, Montgomery, Samuel T., Frey, Dario L., Brown, Milton R., Schultz, Carsten, Guglani, Lokesh, Kicic, Anthony, Peng, Limin, Scholte, Bob J., Mall, Marcus A., Janssens, Hettie M., Stick, Stephen M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Thoracic Society 2019
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444666/
https://ncbi.nlm.nih.gov/pubmed/30281324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201803-0442OC
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