Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis

Rationale: Neutrophils are recruited to the airways of individuals with cystic fibrosis (CF). In adolescents and adults with CF, airway neutrophils actively exocytose the primary granule protease elastase (NE), whose extracellular activity correlates with lung damage. During childhood, free extracel...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Margaroli, Camilla, Garratt, Luke W., Horati, Hamed, Dittrich, A. Susanne, Rosenow, Timothy, Montgomery, Samuel T., Frey, Dario L., Brown, Milton R., Schultz, Carsten, Guglani, Lokesh, Kicic, Anthony, Peng, Limin, Scholte, Bob J., Mall, Marcus A., Janssens, Hettie M., Stick, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444666/
https://ncbi.nlm.nih.gov/pubmed/30281324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201803-0442OC
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