Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis

Rationale: Neutrophils are recruited to the airways of individuals with cystic fibrosis (CF). In adolescents and adults with CF, airway neutrophils actively exocytose the primary granule protease elastase (NE), whose extracellular activity correlates with lung damage. During childhood, free extracel...

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發表在:Am J Respir Crit Care Med
Main Authors: Margaroli, Camilla, Garratt, Luke W., Horati, Hamed, Dittrich, A. Susanne, Rosenow, Timothy, Montgomery, Samuel T., Frey, Dario L., Brown, Milton R., Schultz, Carsten, Guglani, Lokesh, Kicic, Anthony, Peng, Limin, Scholte, Bob J., Mall, Marcus A., Janssens, Hettie M., Stick, Stephen M.
格式: Artigo
語言:Inglês
出版: American Thoracic Society 2019
主題:
Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444666/
https://ncbi.nlm.nih.gov/pubmed/30281324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201803-0442OC
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