Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis

Rationale: Neutrophils are recruited to the airways of individuals with cystic fibrosis (CF). In adolescents and adults with CF, airway neutrophils actively exocytose the primary granule protease elastase (NE), whose extracellular activity correlates with lung damage. During childhood, free extracel...

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Publicat a:Am J Respir Crit Care Med
Autors principals: Margaroli, Camilla, Garratt, Luke W., Horati, Hamed, Dittrich, A. Susanne, Rosenow, Timothy, Montgomery, Samuel T., Frey, Dario L., Brown, Milton R., Schultz, Carsten, Guglani, Lokesh, Kicic, Anthony, Peng, Limin, Scholte, Bob J., Mall, Marcus A., Janssens, Hettie M., Stick, Stephen M.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2019
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444666/
https://ncbi.nlm.nih.gov/pubmed/30281324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201803-0442OC
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