Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

The Foxp3 transcription factor is a crucial determinant of both regulatory T (T(REG)) cell development and their functional maintenance. Appropriate modulation of tolerogenic immune responses therefore requires the tight regulation of Foxp3 transcriptional output, and this involves both transcriptio...

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Udgivet i:Cell Rep
Main Authors: Fleskens, Veerle, Minutti, Carlos M., Wu, Xingmei, Wei, Ping, Pals, Cornelieke E.G.M., McCrae, James, Hemmers, Saskia, Groenewold, Vincent, Vos, Harm-Jan, Rudensky, Alexander, Pan, Fan, Li, Huabin, Zaiss, Dietmar M., Coffer, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444001/
https://ncbi.nlm.nih.gov/pubmed/30917315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.087
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