Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists

Peroxisome Proliferator-Activated Receptor γ (PPARγ) is an important sensor at the crossroad of diabetes, obesity, immunity and cancer as it regulates adipogenesis, metabolism, inflammation and proliferation. PPARγ exerts its pleiotropic functions upon binding of natural or synthetic ligands. The mo...

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Published in:Sci Rep
Main Authors: Sabatino, Lina, Ziccardi, Pamela, Cerchia, Carmen, Muccillo, Livio, Piemontese, Luca, Loiodice, Fulvio, Colantuoni, Vittorio, Lupo, Angelo, Lavecchia, Antonio
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443668/
https://ncbi.nlm.nih.gov/pubmed/30931956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41765-2
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