STING-mediated intestinal barrier dysfunction contributes to lethal sepsis

BACKGROUND: Gut integrity is compromised in abdominal sepsis with increased cellular apoptosis and altered barrier permeability. Intestinal epithelial cells (IEC) form a physiochemical barrier that separates the intestinal lumen from the host's internal milieu and is strongly involved in the mu...

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Udgivet i:EBioMedicine
Main Authors: Hu, Qiongyuan, Ren, Huajian, Li, Guanwei, Wang, Dingyu, Zhou, Quan, Wu, Jie, Zheng, Jiashuo, Huang, Jinjian, Slade, Dominic A., Wu, Xiuwen, Ren, Jianan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443583/
https://ncbi.nlm.nih.gov/pubmed/30878597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.02.055
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