Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study

BACKGROUND: Activated coagulation factor IX (FIXa) consists of a γ-carboxyglutamic acid domain, two epidermal growth factor-like (EGF) domains and C-terminal protease domain. Consensus sequence and biochemical data support the existence of Na(+)-site in FIXa protease domain. However, soaking experim...

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Detaylı Bibliyografya
Yayımlandı:J Thromb Haemost
Asıl Yazarlar: Vadivel, Kanagasabai, Schreuder, Herman A., Liesum, Alexander, Schmidt, Amy. E., Goldsmith, Gunaseelan, Bajaj, S. Paul.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443445/
https://ncbi.nlm.nih.gov/pubmed/30725510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14401
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