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Functional Role of Residue 193 (Chymotrypsin Numbering) in Serine Proteases: Influence of Side Chain Length and β-Branching on the Catalytic Activity of Blood Coagulation Factor XIa
In serine proteases, Gly(193) (chymotrypsin numbering) is conserved with rare exception. Mutants of blood coagulation proteases have been reported with Glu, Ala, Arg or Val substitutions for Gly(193). To further understand the role of Gly(193) in protease activity, we replaced it with Ala or Val in...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2885443/ https://ncbi.nlm.nih.gov/pubmed/18186617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701594j |
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