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Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study
BACKGROUND: Activated coagulation factor IX (FIXa) consists of a γ-carboxyglutamic acid domain, two epidermal growth factor-like (EGF) domains and C-terminal protease domain. Consensus sequence and biochemical data support the existence of Na(+)-site in FIXa protease domain. However, soaking experim...
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| Udgivet i: | J Thromb Haemost |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6443445/ https://ncbi.nlm.nih.gov/pubmed/30725510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14401 |
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