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Interplay between DNA sequence and negative superhelicity drives R-loop structures
R-loops are abundant three-stranded nucleic-acid structures that form in cis during transcription. Experimental evidence suggests that R-loop formation is affected by DNA sequence and topology. However, the exact manner by which these factors interact to determine R-loop susceptibility is unclear. T...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6442632/ https://ncbi.nlm.nih.gov/pubmed/30850542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819476116 |
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