Lipoprotein lipase is active as a monomer

Lipoprotein lipase (LPL), the enzyme that hydrolyzes triglycerides in plasma lipoproteins, is assumed to be active only as a homodimer. In support of this idea, several groups have reported that the size of LPL, as measured by density gradient ultracentrifugation, is ∼110 kDa, twice the size of LPL...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Beigneux, Anne P., Allan, Christopher M., Sandoval, Norma P., Cho, Geoffrey W., Heizer, Patrick J., Jung, Rachel S., Stanhope, Kimber L., Havel, Peter J., Birrane, Gabriel, Meiyappan, Muthuraman, Gill, John E., Murakami, Masami, Miyashita, Kazuya, Nakajima, Katsuyuki, Ploug, Michael, Fong, Loren G., Young, Stephen G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442593/
https://ncbi.nlm.nih.gov/pubmed/30850549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900983116
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