Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis

Lipoprotein lipase (LPL) is responsible for the intravascular processing of triglyceride-rich lipoproteins. The LPL within capillaries is bound to GPIHBP1, an endothelial cell protein with a three-fingered LU domain and an N-terminal intrinsically disordered acidic domain. Loss-of-function mutations...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Birrane, Gabriel, Beigneux, Anne P., Dwyer, Brian, Strack-Logue, Bettina, Kristensen, Kristian Kølby, Francone, Omar L., Fong, Loren G., Mertens, Haydyn D. T., Pan, Clark Q., Ploug, Michael, Young, Stephen G., Meiyappan, Muthuraman
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358717/
https://ncbi.nlm.nih.gov/pubmed/30559189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817984116
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