A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer

Glioblastoma multiforme (GBM; grade IV astrocytoma) is the most prevalent and aggressive form of primary brain cancer. A subpopulation of multipotent cells termed GBM cancer stem cells (CSCs) play a critical role in tumor initiation, tumor maintenance, metastasis, drug resistance, and recurrence fol...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lucki, Natasha C., Villa, Genaro R., Vergani, Naja, Bollong, Michael J., Beyer, Brittney A., Lee, Jae Wook, Anglin, Justin L., Spangenberg, Stephan H., Chin, Emily N., Sharma, Amandeep, Johnson, Kevin, Sander, Philipp N., Gordon, Perry, Skirboll, Stephen L., Wurdak, Heiko, Schultz, Peter G., Mischel, Paul S., Lairson, Luke L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442583/
https://ncbi.nlm.nih.gov/pubmed/30846550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816626116
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