A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer

Glioblastoma multiforme (GBM; grade IV astrocytoma) is the most prevalent and aggressive form of primary brain cancer. A subpopulation of multipotent cells termed GBM cancer stem cells (CSCs) play a critical role in tumor initiation, tumor maintenance, metastasis, drug resistance, and recurrence fol...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Lucki, Natasha C., Villa, Genaro R., Vergani, Naja, Bollong, Michael J., Beyer, Brittney A., Lee, Jae Wook, Anglin, Justin L., Spangenberg, Stephan H., Chin, Emily N., Sharma, Amandeep, Johnson, Kevin, Sander, Philipp N., Gordon, Perry, Skirboll, Stephen L., Wurdak, Heiko, Schultz, Peter G., Mischel, Paul S., Lairson, Luke L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442583/
https://ncbi.nlm.nih.gov/pubmed/30846550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816626116
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